Dr. Piotr Bartyzel received his undergraduate and graduate education in Chemical Engineering and Organic Chemistry from the Cracow University of Technology (Politechnika) and Ph.D. in Pharmaceutical Sciences from the Collegium Medicum of the Jagiellonian University (Akademia Medyczna), royal charter 1364, in Cracow, Poland.
Dr. Piotr Bartyzel joined the Walker Cancer Research Institute, Inc. at the Florida Natural Products Division in Tallahassee, Florida in January 1999. Before joining the WCRI Dr. P. Bartyzel served as a Visiting Scientist at the Medical College of Virginia of the Virginia Commonwealth University in Richmond, Virginia and a research faculty at the College of Pharmacy and the Research Institute of Pharmaceutical Sciences of the University of Mississippi (Ole Miss) at University, Mississippi.
Over the last ten years his research interests gradually shifted from the studies of the central nervous system (serotonin) to immunomodulation (complement cascade) to be driven recently by the humanitarian needs deeply into the cancer issue (potential anticancer agents of natural products /marine origin).
In April 2002 he left his position with WCRI, but still keeps a
professional relation with the Institute, as a Consultant.
STATEMENT OF RESEARCH OBJECTIVES
Dr. P. Bartyzel major objective and research methodology is to apply the rationality of medicinal chemistry to natural products research with a goal towards developing anti-cancer pharmaceuticals.
Executing the WCRI mission, Dr. P. Bartyzel is
currently studying bio-accumulators of cytotoxic secondary metabolites
having properties to inhibit growth/proliferation of tumor cells. These
research goals are being pursued by studying marine invertebrates, plants, and fungi
available at the Florida Coast of the Gulf of Mexico.
Synthesis of GABA Analogs 1976 and Potential Antiinflammatory Agents 1977 - 1978. CNS Agents: Anxiolytics, Antidepressants and Neuroleptics 1981 - 1985. Institute of Pharmacology of the Polish Academy of Sciences at Cracow, Poland.
Medicinal Chemistry of Serotonin Receptor Ligands 1989 - 1991. Medical College of Virginia, Virginia Commonwealth University at Richmond, Virginia.
Complement Cascade Inhibitors Designed on Natural Products Models 1992 - 1995*. Marine Natural Products (Pacific) - Isolation and Semisynthetic Modification in Search for Antitumor Agents with Enhanced Activity 1996 - 1997. Nitric Oxide Synthetase Inhibitors 1998. College of Pharmacy and Research Institute of Pharmaceutical Sciences, The University of Mississippi at University, Mississippi.
*Invited Member of the Drug Discovery Group 1992 - 1995. The Research Institute of Pharmaceutical Sciences of the University of Mississippi.
Potential Anticancer Agents of Natural Products/Marine Origin 1999 -
present. The Walker Cancer Research Institute, Florida Natural Products
Laboratory, Tallahassee, Florida.
B.Sc. 1975, M.Sc. 1981 - Cracow University of Technology (Politechnika),
Cracow, Poland. PH.D. Pharmaceutical Sci. 1989 - Collegium Medicum of
the Jagiellonian University - 1364 (Akademia Medyczna), Cracow, Poland.
BOOK CHAPTERS and JOURNAL PUBLICATIONS
El Sayed K.A., Dunbar D.C., Bartyzel P., Zjawiony J.K., Day W., Hamann M.T: Marine Natural Products as Leads to Develop New Drugs and Insecticides. In Biologically Active Natural Products: Pharmaceuticals. Cutler Horace G., Ed., CRC Press 2000; Chapter 17, pp 233 - 252.
Glennon R.A., Westkaemper R.B., Bartyzel P.: Medicinal Chemistry of Serotonergic Agents. In Receptor Biochemistry and Methodology, Vol. 15, Venter J.C. and Harrison L.C., Eds.: Wiley-Liss, Inc. 1991; Chapter 2, pp 19 - 64.
Bartyzel P., Misztal S.: Synthesis of 1- Spiropiperidino-1,2,3,4-tetrahydro-beta-carbolines and Their Transformations. In F.E.C.S. Chem. Biotechnol. Biol. Act. Nat. Prod., [Proc.]; Vol. 4, VCH Publishers, NY 1987; pp 145 - 147.
Zjawiony J.K., Bartyzel P., Hamann M.T. "Chemistry of Puupehenone: 1,6-Conjugate Addition to its Quinone-Methide System". J. Nat. Prod., 1998, 61, 1502 - 1508.
Scesney S.M., Bradbury B.J., Kaufman T.S., Bartyzel P., Lee C., Sindelar R.D., Marsh Jr., H.C. "Synthetic Analogues of the Natural Product K-76COOH Inhibit the Activation of Complement C-5". FASEB Journal, 1994, 8, No. 5. 3957.
Mokrosz M.J., Bartyzel P., Mokrosz J.L. "Structure and Spectral Properties of beta - Carbolines. 5. Synthesis and Stereochemistry of New Trihydrodiazabicyclo[3.m.n.]alkano-[4',5':1,2]pyrido[3,4-b]indole Ring System". J. Heterocycl. Chem., 1993, 30, 1543 - 1548.
Glennon R.A., Raghupathi R., Bartyzel P., Teitler M., Leonhardt S. "Binding of Phenylalkylamine Derivatives at 5-HT1C and 5-HT-2 Serotonin Receptors: Evidence for a Lack of Selectivity". J. Med. Chem., 1992, 35, 734 - 740.
Glennon R.A., Bartyzel P., Teitler M. "Binding of Benz[e]- and Benzo[g]-fused Tryptamine Derivatives at Serotonin Receptors: Evidence for a Region of Bulk Tolerance". Med. Chem. Res., 1991, 1, 201 - 206.
Bartyzel P., Raghupati R., Teitler M., Glennon R.A. "Attempt to Develop 5-HT1C Selective Phenylalkylamines". Virginia J. Sci., 1991, 42, 232.
Dukat M., Bartyzel P., Teitler M., Glennon R.A. "Development of 5-HT-3 Selective Serotonin Agonists". Virginia J. Sci., 1991, 42, 235.
Bartyzel P., Misztal S., Tatarczynska E., Chojnacka-Wojcik E. "Novel 1 - Spiropiperidine-1,2,3,4 - tetrahydro - beta - carbolines of Potential Biological Interest". Virginia J. Sci., 1990, 41, 104.
Bartyzel P., Misztal S., Tatarczynska E., Chojnacka-Wojcik E. "N - Aminoalkyl Derivatives of 1,2,3,4 - Tetrahydro-beta-carboline-1-spiro-4'-N'-benzylpiperidine - A Putative Way to Novel Anxiolytic Agents". Pol. J. Pharmacol. Pharm., 1989, 41, 495 - 503.
Bala M., Bartyzel P., Makulska E., Misterek K., Stochla K. "Synthesis and Preliminary Pharmacological Screening of 4 - Methylamino-2-phenylquinoline-3-carboxamides". Pol. J. Pharmacol. Pharm., 1986, 38, 115 - 124.
Misztal S., Chojnacka-Wojcik E., Bartyzel P., Moskal A., Tatarczynska E., Wiczynska B., Lewandowska A. "Synthesis and Pharmacological Properties of N - Arylpiperazine-N'-alkylindanes". Pol. J. Pharmacol. Pharm., 1984, 36, 697 - 703.
Misztal S., Bartyzel P., Chojnacka-Wojcik E., Tatarczynska E.,
Sypniewska M. "Synthesis and Pharmacological Properties of N-Aroyl-beta-(1-indanyl)-ethylamines".
Pol. J. Pharmacol. Pharm., 1980, 32, 577 - 585.
Bartyzel P.: Invited Seminar Lecture (1 hour) "Synthesis and CNS Activity of Spiropiperidine- and Azabicyclic Derivatives of 1,2,3,4 - Tetrahydro-beta-carbolines. April 28, 1990. School of Pharmacy, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA
Bartyzel P.: Five (5) conference lectures at:
George Mason University, Fairfax, VA (Virg. Acad. Sci. Meeting, May
1990); Virginia Polytechnic and State University, Blacksburg, VA (Virg.
Acad. Sci. Meeting, May 1991); University of California at Santa Cruz,
CA (Am. Soc. Pharmacog., 37th Annual Meeting, July 1996); University of
Arkansas for Medical Sciences, Little Rock, AR (MALTO Meeting, May
1997); University of Iowa at Iowa City, IO (Am. Soc. Pharmacog., 38th
Annual Meeting, July 1997).
The University of Mississippi CERTIFICATE of APPRECIATION, The University of Mississippi, University, MS, 1997.
Honored Member of INTERNATIONAL WHO'S WHO of Professionals Millennium
Edition. WHO'S WHO Historical Society2000.
Dr. Piotr Bartyzel is a member of the American Chemical Society (Medicinal Chemistry) and the American Institute of Chemical Engineers (Food, Pharmaceuticals and Bio-Engineering).